The Impact of Sex on the Outcomes of Prosthetic Joint Infection Treatment with Debridement, Antibiotics and Implant Retention: A Systematic Review and Individual Patient Data Meta-analysis

AL Choong; C Shadbolt; E Choong; T Spelman; E Muñoz-Mahamud; J Lora-Tamayo; K Kim; M Wouthuyzen-Bakker; M Spangehl; M Chayakulkeeree; SW Young; PFM Choong; MM Dowsey

Journal article

The Impact of Sex on the Outcomes of Prosthetic Joint Infection Treatment with Debridement, Antibiotics and Implant Retention: A Systematic Review and Individual Patient Data Meta-analysis

AL Choong, C Shadbolt, E Choong, T Spelman, E Muñoz-Mahamud, J Lora-Tamayo, K Kim, M Wouthuyzen-Bakker, M Spangehl, M Chayakulkeeree, SW Young, PFM Choong, MM Dowsey

Journal of the American Academy of Orthopaedic Surgeons Global Research and Reviews | Published : 2022

DOI: 10.5435/JAAOSGlobal-D-22-00102

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Abstract

Background: The influence of sex on the failure of débridement antibiotics and implant retention (DAIR) for treating prosthetic joint infection (PJI) is important for decision-making, patient counseling, and equitable health care. However, very few studies in the orthopaedic literature conduct sex-specific analyses. Aim: The primary aim was to determine whether sex influences treatment success after DAIR. Methods: A systematic review and individual patient data (IPD) meta-analysis was conducted. MEDLINE (Ovid), EMBASE (Ovid), Web of Science, and Google Scholar were searched, and IPD was requested via e-mail. Patients who underwent DAIR after developing PJI within 12 months of a primary total..

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University of Melbourne Researchers

Cade Shadbolt Author

Timothy Spelman Author

Peter Choong Author

Michelle Dowsey Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

Dr. Dowsey holds an NHMRC Career Development Fellowship (1122526) and a University of Melbourne Dame Kate Campbell Fellowship. Dr. P.F.M. Choong holds an NHMRC Practitioner Fellowship (1154203). Shadbolt acknowledges being supported by an Australian Government Research Training Program Scholarship.